Toward Ecosophy

It depends very much on the nature of the energies. Epidemics and crop failures are among the possibilities, but there are others -- weather, for example, depends as much on the etheric as on the material plane, and there are dysfunctions in the human life force that don't express themselves in disease as such. As for the psychological effects, it really varies from person to person. If you've got some degree of self-knowledge and self-mastery, once things move definitively to the lower astral and etheric, you'll experience a clearing of the mental murkiness -- but those people whose minds are fixated on the material plane will not experience that. Expect them to behave more and more mechanically and oddly until after the crisis is over.