Note that the study did not distinguish between whether the vitamin D levels were obtained via supplementation or not but other studies cited do address that question (also discussed in the substack cited above).
It would be fascinating to see this study repeated but with additional vax status information. I hypothesize that the vax status would only enter the problem in an indirect way by affecting serum 25-hydroxyvitamin D (25(OH)D) levels in the sense that each jab results in a step down in levels in the following way (via http://www.drdavidgrimes.com/):
I also suspect the same mechanism to be operating after each infection resulting in further increased susceptibility to reinfection (a positive feedback). This would be consistent with reinfections being subject to, and more jabbed having more, severe outcomes.
I hypothesize that fancy pants hypotheses of immune tolerance or antigenic imprinting are second-order effects at best and these are subordinate to first-order serum 25-hydroxyvitamin D (25(OH)D) levels of which a large majority of the population are deficient (< 50 ng/mL) even in summer time. However, I have not yet seen actual measurements confirming the above (second) plot which I believe is a conjecture on the part of the author.
Has anyone seen any data to help/hinder this hypothesis? I would want to see continual (time series) measurement of 25(OH)D levels through infection/vaccination.
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branchandroot
vitamin D
Date: 2022-08-16 08:08 pm (UTC)Note that the study did not distinguish between whether the vitamin D levels were obtained via supplementation or not but other studies cited do address that question (also discussed in the substack cited above).
It would be fascinating to see this study repeated but with additional vax status information. I hypothesize that the vax status would only enter the problem in an indirect way by affecting serum 25-hydroxyvitamin D (25(OH)D) levels in the sense that each jab results in a step down in levels in the following way (via http://www.drdavidgrimes.com/):
I also suspect the same mechanism to be operating after each infection resulting in further increased susceptibility to reinfection (a positive feedback). This would be consistent with reinfections being subject to, and more jabbed having more, severe outcomes.
I hypothesize that fancy pants hypotheses of immune tolerance or antigenic imprinting are second-order effects at best and these are subordinate to first-order serum 25-hydroxyvitamin D (25(OH)D) levels of which a large majority of the population are deficient (< 50 ng/mL) even in summer time. However, I have not yet seen actual measurements confirming the above (second) plot which I believe is a conjecture on the part of the author.
Has anyone seen any data to help/hinder this hypothesis? I would want to see continual (time series) measurement of 25(OH)D levels through infection/vaccination.