Interaction between Yersinia pestis and the Host Immune System
"By the bite of an infected rodent flea, Y. pestis may invade directly into the host through the barrier structure of the host skin and encounter phagocytes such as polymorphonuclear leukocytes (PMNs) (predominantly neutrophils) and macrophages at the site of invasion. Most of them might be killed by neutrophils. However, the facultative intracellular Y. pestis preferentially infects host macrophages, possibly via recognition of specific surface-associated CCR5 molecules (33), and survives inside of macrophages at the early stage of infection. After proliferation and expression of various virulence determinants in macrophages, Y. pestis can be released into the extracellular compartment and spread systemically with acquisition of phagocytosis resistance. During this process, Y. pestis may circumvent destruction by the components of the host innate immune system"
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branchandroot
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Date: 2024-07-12 05:14 pm (UTC)https://journals.asm.org/doi/full/10.1128/iai.01517-07
Interaction between Yersinia pestis and the Host Immune System
"By the bite of an infected rodent flea, Y. pestis may invade directly into the host through the barrier structure of the host skin and encounter phagocytes such as polymorphonuclear leukocytes (PMNs) (predominantly neutrophils) and macrophages at the site of invasion. Most of them might be killed by neutrophils. However, the facultative intracellular Y. pestis preferentially infects host macrophages, possibly via recognition of specific surface-associated CCR5 molecules (33), and survives inside of macrophages at the early stage of infection. After proliferation and expression of various virulence determinants in macrophages, Y. pestis can be released into the extracellular compartment and spread systemically with acquisition of phagocytosis resistance. During this process, Y. pestis may circumvent destruction by the components of the host innate immune system"
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