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Open (More or Less) Post on Covid 86
As we proceed through the second year of these open posts, it's pretty clear that the official narrative is cracking as the toll of deaths and injuries from the Covid vaccines rises steadily and the vaccines themselves demonstrate their total uselessness at preventing Covid infection or transmission. It's still important to keep watch over the mis-, mal- and nonfeasance of our self-proclaimed health gruppenfuehrers, and the disastrous results of the Covid mania, but I think it's also time to begin thinking about what might be possible as the existing medical industry reels under the impact of its own self-inflicted injuries. So it's time for another open post. The rules are the same as before:
1. If you plan on parroting the party line of the medical industry and its paid shills, please go away. This is a place for people to talk openly, honestly, and freely about their concerns that the party line in question is dangerously flawed and that actions being pushed by the medical industry et al. are causing injury and death. It is not a place for you to dismiss those concerns. Anyone who wants to hear the official story and the arguments in favor of it can find those on hundreds of thousands of websites.
2. If you plan on insisting that the current situation is the result of a deliberate plot by some villainous group of people or other, please go away. There are tens of thousands of websites currently rehashing various conspiracy theories about the Covid-19 outbreak and the vaccines. This is not one of them. What we're exploring is the likelihood that what's going on is the product of the same arrogance, incompetence, and corruption that the medical industry and its tame politicians have displayed so abundantly in recent decades. That possibility deserves a space of its own for discussion, and that's what we're doing here.
3. If you plan on using rent-a-troll derailing or disruption tactics, please go away. I'm quite familiar with the standard tactics used by troll farms to disrupt online forums, and am ready, willing, and able -- and in fact quite eager -- to ban people permanently for engaging in them here. Oh, and I also lurk on other Covid-19 vaccine skeptic blogs, so I'm likely to notice when the same posts are showing up on more than one venue.
4. If you don't believe in treating people with common courtesy, please go away. I have, and enforce, a strict courtesy policy on my blogs and online forums, and this is no exception. The sort of schoolyard bullying that takes place on so many other internet forums will get you deleted and banned here. Also, please don't drag in current quarrels about sex, race, religions, etc. No, I don't care if you disagree with that: my journal, my rules.
With that said, the floor is open for discussion.
Tolerance
It is a long piece and interesting to read (I haven't yet read it all though). Interesting is that it connects the IgG2 --> IgG4 replacement with several pathologies that we are all too familiar with. From the summary:
"In conclusion, the immune tolerance mechanism induced by mRNA vaccines could
have at least 6 negative unintended consequences:
1) By ignoring the spike protein synthesized as a consequence of vaccination, the host
immune system becomes vulnerable to re-infection with the new Omicron subvariants,
allowing for free replication of the virus once a re-infection takes place. In this situation,
we propose that even these less pathogenic Omicron subvariants could cause significant
harm and even death in individuals with comorbidities and immuno-compromised.
2) mRNA and inactivated vaccines temporally impair interferon signaling [125,126],
causing immune suppression and leaving the individual in a vulnerable situation against
any other pathogen. In addition, this immune suppression could allow the re-activation
of latent viral, bacterial, or fungal infections, and might also allow uncontrolled growth of
cancer cells [127].
3) A tolerant immune system can allow SARS-CoV-2 persistence in the host and
promote the establishment of a chronic infection, similarly to that generated by the hepatitis
B virus (HBV), the human immune deficiency virus (HIV), and the hepatitis C virus
(HCV) [128].
4) The combined immune suppression (produced by SARS-CoV-2 infection and
further enhanced by vaccination) could explain a plethora of autoimmune conditions, cancers,
re-infections, and deaths temporally associated with both. It is conceivable that the
excess deaths reported in several highly COVID-19-vaccinated countries may be explained,
in part, by this combined immunosuppressive effect.
5) Repeated vaccination could also lead to auto-immunity: In 2009, the results of an
important study went largely unnoticed. Researchers discovered that in mice that are
otherwise not susceptible to spontaneous autoimmune disorders, repeated administration
of the antigen promotes systemic autoimmunity. The development
of CD4+ T cells that can induce autoantibodies (autoantibody-inducing CD4+ T
cells, or aiCD4+ T cells), which had their T cell receptors (TCR) modified, was
triggered by excessive stimulation of CD4+ T cells. The aiCD4+ T cell was generated
by new genetic TCR modification rather than a cross-reaction. The excessively
stimulated CD8+ T cells induced them to develop into cytotoxic T lymphocytes
(CTL) that are specific for an antigen. These CTLs were able to mature further
by antigen cross-presentation, so in that situation, they induced autoimmune
tissue damage resembling systemic lupus erythematosus (SLE) [129]. According to
the self-organized criticality theory, when the immune system of the host is continually
overstimulated by antigen exposure at concentrations that are higher (see page 11) than
the immune system's self-organized criticality can tolerate, systemic autoimmunity inevitably
occurs [130].
It has been proposed that the amount and duration of the spike protein produced are
presumably affected by the higher mRNA concentrations in the mRNA-1273 vaccine (100
μg) compared to the BNT162b2 vaccine (30 μg) [94]. Thus, it is probable that the spike
protein produced in response to mRNA vaccination is too high and last too much time in
the body. That overwhelms the capacity of the immune system, thus leading to autoimmunity
[129,130]. Indeed, several investigations have found that COVID-19 immunization
is associated with the development of autoimmune responses [131-148].
6) Increased IgG4 levels induced by repeated vaccination can lead to autoimmune
myocarditis: It has been discovered that IgG4 antibodies can also cause an autoimmune
reaction by impeding the immune system`s ability to be suppressed by regulatory T cells
[86]. Patients using immune checkpoint inhibitors alone or in combination have been
linked to occurrences of acute myocarditis [87-90], sometimes with lethal consequences
[91]. As anti-PD-1 antibodies are class IgG4, and these antibodies are also induced by repeated
vaccination, it is plausible to suggest that excessive vaccination is associated with
the occurrence of an increased number of myocarditis cases and sudden cardiac deaths.
Finally, these negative outcomes are not expected to affect all people who have received
these mRNA vaccines. Individuals with genetic susceptibility, immune deficiencies,
and co-morbidities probably would be the most likely to be affected. However, this
gives rise to a disturbing paradox: if people who are the most affected by the COVID-19
disease (the elderly, diabetics, hypertensive, and immunocompromised people like those
with HIV) are also more susceptible to suffering the negative effects of mRNA vaccines,
is it then justified to booster them? As Omicron subvariants have been demonstrated to
be less pathogenic, and mRNA vaccines do not protect against re-infection, clinicians
should be aware of the possible detrimental effects on the immune system by administering
boosters."
I'm curious what others think of this. Can so many pathologies associated with the vaxx get pinned onto the IgG4 increase?
PS It might be worthwile to save a copy of the piece before it gets "retracted".
Re: Tolerance
(Anonymous) 2023-03-30 04:36 pm (UTC)(link)Re: Tolerance
Some thoughts on this paper:
1. The authors are from universities, research institutes, and hospitals in Florida, Saudi Arabia, Egypt, Canada, and Mexico. I'd be curious to learn how they found each other and decided to collaborate on this.
2. It's a hypothesis paper, presenting a possible mechanism that could explain published findings rather than presenting the findings themselves. It is in some ways a more academic and informed presentation of my tolerance hypothesis, but with added nuance and new pathways to harm.
3. Some key quotes (and thoughts):
"In this paper, we provide the scientific rationale showing that repeated vaccination with mRNA vaccines generates an immune tolerance mechanism, thereby favoring unopposed SARS-CoV-2 replication. The immediate consequence of this tolerance is the establishment of a permissive state of the host leading to chronic infection and other unintended consequences induced by mRNA vaccination."
"IgG4 antibodies do, however, function as tissue-damaging autoantibodies in some disor-
ders, as seen in myasthenia gravis [47], idiopathic membranous glomerulonephritis [48],
and pemphigus vulgaris (PV) [49]."
(The idea that "tolerance" IgG4 antibodies might directly contribute to pathogenicity and autoimmunity is new to me. I do personally know of two people who have been debilitated by myasthenia gravis since the vaccine rollout.)
"More IgG4 seems to be linked to more aggressive cancer growth, and both
were strongly associated with higher cancer malignancy and poor prognosis. It was dis-
covered that IgG4 can contend with IgG1 (as shown in Figure 3) in binding to Fc receptors
present on some immune cells in vitro. This competition results in the inhibition of typical
immune responses against cancer cells, such as cell and complement cytotoxicity, and cell
phagocytosis, which are mediated by IgG1 antibodies."
(So now we have another possible explanation for turbo-cancer, and it appears that IgG4 effects are not necessarily specific to the target antigen.)
"However, they were unable to detect this rise after two
doses of the AZD1222 vaccine in uninfected individuals up to day 270, showing that only
mRNA vaccines induce produce detectable and prolonged IgG4 responses until day 270.
Importantly, in patients who had a previous COVID-19 infection (before vaccination),
IgG4 did not rise, even after mRNA injections, implying that those with higher IgG4 levels
are uninfected people who were immunized with mRNA vaccines before having their
COVID-19 infection [94]."
(Summarizing previous findings, IgG4 tolerance appears to be only induced by the mRNA injections, and only in the absence of prior infection.)
"T cells can undergo a process known as "terminal differentiation" when vaccines
are given in high concentrations, T cells undergo this process and become highly special-
ized, losing the capacity to divide and procreate. The immune system becomes ex-
hausted as a result and is unable to mount a successful defense against subsequent ill-
nesses. This is a problem since it might undermine the protective advantages of vaccina-
tions. To balance the advantages of immunological protection and the potential disad-
vantages of immune exhaustion, it is crucial to carefully determine the ideal dose of vac-
cines."
(Separately from IgG4 antibody effects, T cell tolerance can also be induced by repeated exposure to high antigen concentrations. The authors go on to note that a more typical vaccination strategy would be a high antigen dose for initial vaccination followed by much lower doses for boosting, which would mimic the natural pattern of immunity being developed during acute illness and then strengthened during subsequent exposures in which the pathogen is destroyed before replicating to high levels.)
"It is important to note that the probability of contracting malaria increased by around
three times when non-neutralizing IgG4 levels doubled. Up to the age of 24 months, IgG1
and IgG3 demonstrated 51% and 56% protective effects respectively, however, IgG4 was
linked to a higher risk of malaria infection throughout this age range [105]. It's interesting
to note that a separate study also found a link between high IgG4 levels and a higher risk
of infection and malaria exacerbations [111]."
(The authors summarize findings from failed HIV and malaria vaccine trials [not using mRNA technology, but using repeated injection of high antigen doses] in which IgG4 antibodies were produced in some subjects and correlated with loss of efficacy or negative efficacy.)
4. I'm still surprised that none of the tolerance treatises cite this paper - https://www.science.org/doi/10.1126/science.aay3638 (summaraized here: https://www.nature.com/articles/s41587-021-00880-0) - which proved that mRNA vaccination technology can specifically induce tolerance when that is the goal. I'm also surprised they don't more broadly explore the unique mechanism of mRNA vaccination - i.e. otherwise-healthy cells induced to become antigen factories in the absence of any other markers of infection - and why that might logically be expected to induce tolerance responses.
5. The authors are positing both *specific* tolerance - increased susceptibility to SARS-CoV2 - and *broad* tolerance (increased susceptibility to other pathogens and cancer). They appear to be suggesting three mechanisms for the broad tolerance: A) direct (but transient) suppression of immune function following vaccination, B) suppression of immune function due to chronic/persistent SARS-CoV2 infection, and C) direct nonspecific effects of high IgG4 levels on regulatory T cells and tumor-fighting pathways. Mechanism C is new to me, but not entirely surprising.
6. The authors are also positing "tolerance-induced autoimmunity", which seems counterintuitive given that the states are effectively opposites. However, one component of my tolerance hypothesis was that disruption of the immune system's delicate "self/non-self" discrimination system would lead to errors in both directions - toward tolerance and autoimmunity - and indeed this seems to be documented in the case of IgG4 imbalances.
Re: Tolerance
It appears from this reference (https://pubmed.ncbi.nlm.nih.gov/34598853/) that covid infection can also induce IgG4 responses in some people, and that this is bad with regard to severity/mortality. So perhaps the loss of overall immunity in the population is another vax+virus effect, with the vax being worse but not exactly an either/or situation.
Re: Tolerance
(Anonymous) 2023-03-30 07:49 pm (UTC)(link)Re: Tolerance
(Anonymous) 2023-03-31 11:39 am (UTC)(link)Re: Tolerance
The potential implication is that if the boosters are generating widespread increases in IgG4, that could be expected to make covid infection more severe/deadly.