It has very little in the way of serious negative karma; the most important issue I've noticed is a tendency to exaggerate eccentricity. The connection with the more destructive and dogmatic forms of orthodoxy is far enough back, and has been worked through thoroughly enough by the intervening generations of bishops, priests, priestesses, and laity, that it's pretty clean.

The positive side includes a focus on healing energies and on individual spiritual perception. That said, I certainly recommend spending ample time on discernment before committing to anything like this. It's also entirely appropriate to explore the minor orders and reflect on that experience before going further.