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Open (More or Less) Post on Covid 54

So it's time for another open post. The rules are the same as before:
1. If you plan on parroting the party line of the medical industry and its paid shills, please go away. This is a place for people to talk openly, honestly, and freely about their concerns that the party line in question is dangerously flawed and that actions being pushed by the medical industry et al. are causing injury and death. It is not a place for you to dismiss those concerns. Anyone who wants to hear the official story and the arguments in favor of it can find those on hundreds of thousands of websites.
2. If you plan on insisting that the current situation is the result of a deliberate plot by some villainous group of people or other, please go away. There are tens of thousands of websites currently rehashing various conspiracy theories about the Covid-19 outbreak and the vaccines. This is not one of them. What we're exploring is the likelihood that what's going on is the product of the same arrogance, incompetence, and corruption that the medical industry and its tame politicians have displayed so abundantly in recent decades. That possibility deserves a space of its own for discussion, and that's what we're doing here.
3. If you plan on using rent-a-troll derailing or disruption tactics, please go away. I'm quite familiar with the standard tactics used by troll farms to disrupt online forums, and am ready, willing, and able -- and in fact quite eager -- to ban people permanently for engaging in them here. Oh, and I also lurk on other Covid-19 vaccine skeptic blogs, so I'm likely to notice when the same posts are showing up on more than one venue.
4. If you don't believe in treating people with common courtesy, please go away. I have, and enforce, a strict courtesy policy on my blogs and online forums, and this is no exception. The sort of schoolyard bullying that takes place on so many other internet forums will get you deleted and banned here. No, I don't care if you disagree with that: my journal, my rules.
With that said, the floor is open for discussion.
vitamin D
Note that the study did not distinguish between whether the vitamin D levels were obtained via supplementation or not but other studies cited do address that question (also discussed in the substack cited above).
It would be fascinating to see this study repeated but with additional vax status information. I hypothesize that the vax status would only enter the problem in an indirect way by affecting serum 25-hydroxyvitamin D (25(OH)D) levels in the sense that each jab results in a step down in levels in the following way (via http://www.drdavidgrimes.com/):
I also suspect the same mechanism to be operating after each infection resulting in further increased susceptibility to reinfection (a positive feedback). This would be consistent with reinfections being subject to, and more jabbed having more, severe outcomes.
I hypothesize that fancy pants hypotheses of immune tolerance or antigenic imprinting are second-order effects at best and these are subordinate to first-order serum 25-hydroxyvitamin D (25(OH)D) levels of which a large majority of the population are deficient (< 50 ng/mL) even in summer time. However, I have not yet seen actual measurements confirming the above (second) plot which I believe is a conjecture on the part of the author.
Has anyone seen any data to help/hinder this hypothesis? I would want to see continual (time series) measurement of 25(OH)D levels through infection/vaccination.
Re: vitamin D
It would be really easy to test whether vaccination and/or infection reduces vitamin D levels and for how long. Until we have such data I'm not inclined to suspect that vitamin D is a primary driving factor.
It's almost certainly not going to be a sequential step down like that, because serum D levels will tend to recover after each acute immune insult. If levels don't recover, there would need to be some other driving factor - e.g. persistent immune activation that is continuously consuming D - in which case vitamin D deficiency would be a the second-order effect.
Re: vitamin D
Now that I think about it, one wouldn't need a time series but simply reconstruct annual cycles such as that in Fig. 1. The sine curves would simply offset downwards depending on the #vaxes, for example.
Rather than the linear step down depicted, I would expect the step downs to become steeper with each jab as recipients would be less able to clear the spikes due to progressively lower 25(OH)D availability. Recovery in 25(OH)D levels would only occur in summer or if supplements were being taken.
Re: vitamin D
Re: vitamin D
(Anonymous) 2022-08-17 10:11 am (UTC)(link)TTF
Re: vitamin D
(Anonymous) 2022-08-17 03:18 pm (UTC)(link)Vitamin D for COVID-19: real-time meta analysis of 219 studies
Covid Analysis, Aug 16, 2022, Version 185 — updated Lakkireddy [Lakkireddy]
Impressive!